In a previous blog, i reported on the preliminary results from sprint, a clinical trial that examined whether a systolic blood pressure target of 120 mm hg or less would be better than a target. Hypertension is highly prevalent in the adult population in the united states, especially among persons older than 60 years of age, and affects approximately 1 billion adults worldwide. Systolic blood pressure intervention trial sprint professional. Nov 12, 2015 new england journal of medicine source reference. Sprint examined effects of more intensive antihypertensive therapy than currently recommended participants were us adults. The new england journal of medicine 2290 n engl j med 374.
A primary cardiovascular prevention trial in people. In august 2015, the sprint trial was stopped after 3. The new england journal of medicine n engl j med 373. Trial sprint research group is pro vided in the supplementary appendix, available at. Justification for chronic kidney disease subgroup in sprint. Our results are consistent with, and extend, previous findings by definitively showing a significant and large reduction in hospitalisation for patients with nyha class iii heart failure who were managed with a wireless implantable haemodynamic monitoring system. Pdf a randomized trial of intensive versus standard blood. The new england journal of medicine nejm today named three teams hailing from universities in israel and the united states as the winners of the sprint data analysis challenge, which encouraged.
Links to the sprint trial and to nejm resources and to www. Effect of intensive vs standard blood pressure control on. Wright jt jr, et al a randomized trial of intensive versus standard bloodpressure control sprint n engl j med 2015. For group comparison of incidence, hazard ratio, 0. Notable articles of 2015 the new england journal of. A trial coordinating center served as a data and biostatistical core. Lower systolic blood pressure is associated with lower risk for. Sprint mind trial finds lower risk of mci and dementia with. Sprint challenge will demonstrate the potential of sharing of clinical trial data boston, mass.
Leading up to the summit, the sprint data analysis challenge was held between november. September 28, 2016 to demonstrate the potential of sharing clinical trial data to develop undiscovered research findings, the new england journal of medicine nejm is sponsoring the sprint data analysis challenge. A complete list of the members of the systolic blood pressure intervention trial sprint research group is provided in the supplementary appendix, available at nejm. The new england journal of medicine hosts summit to. See the nejm article, a randomized trial of intensive. Nejm is hosting a summit on aligning incentives for sharing clinical data on april 34, 2017. Pdf a randomized trial of intensive versus standard. Nov 26, 2015 sprint was a randomized, controlled, openlabel trial that was conducted at 102 clinical sites organized into 5 clinical center networks in the united states, including puerto rico see the supplementary appendix, available with the full text of this article at nejm. Boston march 20, 2017 the new england journal of medicine nejm will host the aligning incentives for sharing clinical trial data summit and live web event on april 34, 2017 in boston, ma. Meet the nejm sprint challenge winners nejm resident 360. Justification for chronic kidney disease subgroup in sprint american society of hypertension 27th annual meeting, may 20. Systolic blood pressure intervention trial sprint published in november 2015 in new england journal of medicine.
This was a multicenter randomized, controlled, open label clinical trial performed to evaluate a more intensive blood pressure strategy sbp jan 28, 2019 between november 2010 and march 20 more than 9,300 participants were randomized to the two target groups with nearly 4,700 in each group. Nov 26, 2015 a randomized trial of intensive versus standard bloodpressure control. Learn results from the sprint trial on intensive blood pressure management in less than 2 minutes with new nejm quick take video summary. The trial studied persons with a systolic blood pressure of greater than mm hg and increased cardiovascular risk. Systolic blood pressure intervention trial sprint november 9, 2015, nejm.
By focusing on bloodpressure levels, rather than on specific antihypertensive. Justification for chronic kidney disease subgroup in sprint american society of hypertension 27th annual meeting, may 20, 2012 alfred k. The new england journal of medicine announces the sprint data. A randomized trial of intensive versus standard bloodpressure. A substudy of the sprint trial which randomized patients to either a standard group, with a target of less than 140 mm hg, or an intensivetreatment group, with a target of less than 120. This policy may be difficult to implement in other health systems, but imagine what prog1.
Keep in mind that sprint was limited to middleaged and older patients at aboveaverage cv risk and that diabetic patients were excluded because the accord bp researchers had examined. The trial compared the effects of randomization to a treatment program of an intensive sbp goal with randomization to a treatment program of a standard goal. The usual goal blood pressures for accord and sprint trials were trial sprint ppt. Nct01206062 aims to test the hypothesis that lowering systolic bp to less than 120 mmhg reduces. Jul 26, 2018 a substudy of the sprint trial which randomized patients to either a standard group, with a target of less than 140 mm hg, or an intensivetreatment group, with a target of less than 120 mm hg sprint mind looked at 9,361 hypertensive older adults with increased cardiovascular risk but without diagnosed diabetes, dementia or stroke. The goal for the sprint challenge was to explore what could be achieved by sharing. The new england journal of medicine announces the sprint. The new england journal of medicine announces the sprint data analysis challenge sprint challenge will demonstrate the potential of sharing of clinical trial data boston, mass. The systolic blood pressure intervention trial sprint randomized patients aged 50 years or more who had a systolic. The sprint trial, funded by the nhlbi arm of the nih and cosponsored by the niddk, nimds and nia, was based on a working group report pdf link from 2007, which identified the question of targeting low blood pressure i. The addition of information about pulmonary artery pressure to clinical signs and symptoms allows for improved heart failure management. Effect of intensive bloodpressure treatment on patientreported. Nct01206062 aims to test the hypothesis that lowering systolic bp to less than 120 mmhg reduces cardiovascular morbidity and mortality versus a target of less than 140 mmhg among hypertensive, nondiabetic adults 10. Characterizing frailty status in the systolic blood.
Nov 09, 2015 the new england journal of medicine source reference. The new england journal of medicine downloaded from on november 17, 2015. Researchers now have evaluated data from the systolic blood pressure intervention trial sprint. The systolic blood pressure intervention trial sprint randomized patients aged 50 years or more who had a systolic blood pressure sbp equal or greater than mm hg and a high cardiovascular risk to an antihypertensive treatment aimed at achieving an sbp of new england journal of medicine ne. Nov 11, 2015 the sprint trial, published nov 9 in the new england journal of medicine, is the biggest news in blood pressure treatment in many years.
A randomized trial of intensive versus standard bloodpressure control presenter. The trial was designed to identify serious adverse effects expected to be related to more intensive treatment of hypertension. The systolic blood pressure intervention trial sprint, clinicaltrials. Nov 09, 2015 keep in mind that sprint was limited to middleaged and older patients at aboveaverage cv risk and that diabetic patients were excluded because the accord bp researchers had examined this question and showed no significant lowering of adverse cv events with intensive treatment. Systolic blood pressure intervention trial sprint principal. Sprint mind trial finds lower risk of mci and dementia. A randomized trial of intensive versus standard bloodpressure control.
Mackenzie clark, pharmd, bcps university of california, san francisco medical center 1. Characterizing frailty status in the systolic blood pressure. A randomized trial of intensive versus standard blood. The new england journal of medicine announces winners of. The goal for the sprint challenge was to explore what could be achieved by sharing clinical trial data, and to bring trialists, data analysts and patients together for a constructive conversation. The systolic blood pressure intervention trial is the first large prospective randomized controlled trial to demonstrate the benefit of an intensive systolic blood pressure sbp treatment target sprint on. Heterogeneity of treatment effects across sex subgroups was examined by testing for treatment. Ambrosius, phd sprint coordinating center wake forest school of medicine american society of hypertension, inc. The new england journal of medicine is the worlds leading medical journal and website. Effect of a buffered crystalloid solution vs saline on acute. The usual goal blood pressures for accord and sprint trials were the systolic blood pressure intervention trial is the first large prospective randomized controlled trial to demonstrate the benefit of an intensive systolic blood pressure sbp treatment target pdf links to the sprint trial and to nejm resources and to.
This finding is certain to unsettle further the ongoing discussion about what patients and their doctors should do about this common risk factor mildly elevated blood pressure and runs. Nov 09, 2015 learn results from the sprint trial on intensive blood pressure management in less than 2 minutes with new nejm quick take video summary. The sprint trial, funded by the nhlbi arm of the nih and cosponsored by the niddk, nimds and nia, was based on a working group report pdf. Wireless pulmonary artery haemodynamic monitoring in chronic. The sprint trial, published nov 9 in the new england journal of medicine, is the biggest news in blood pressure treatment in many years. Impact of the sprint trial on hypertension management. Pressure intervention trial sprint, which com pared the benefit of treatment of systolic blood pressure to a target of less than 120 mm hg with. Both the primary outcome, which was a composite of mi, acute coronary syndrome acs, stroke, heart failure, or cardiovascular death, and overall death were reduced by. Leading up to the summit, the sprint data analysis challenge was held between november 2016 and march 2017 to explore the potential benefits of sharing data from clinical trials. Hypertension is highly prevalent in the adult population in the united states, especially.
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